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Rankings are computed from publicly available federal and state government datasets, supplemented by a handful of published indexes (such as the Tax Foundation, Child Care Aware of America and Zillow Research). Figures are used as each source publishes them, including the FBI's own state crime estimates; nothing is synthetic or modeled by us, and every source is cited below.

  • Bureau of Labor Statistics, LAUS annual averages·
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  • Bureau of Labor Statistics, OES·
  • IRS Statistics of Income, State-to-State Migration·
  • U.S. Census Bureau, ACS State-to-State Migration Flows·
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Home/SC/Best for Small Business
South Carolina · best for small business · #25 of 50 states

Best Cities for Small Business in South Carolina

South Carolina ranks #25 of 50 for small business, with a small business score of 58.4. Fort Mill is its best city for small business at 76.2.

See all 50 states for small business →

#1 city in SC for small business
Fort Mill76.2
Small Business score out of 100
South Carolina, all states
#25 of 50
Population
30,775
Open Fort Mill →
Tax burden
8.15%
% of income
Fiscal health
54/100
GDP + debt + reserves
Pop. growth
+1.46%
Census estimates
Unemployment
4.5%
BLS LAUS
Economy score
32/100
Income + jobs + growth

South Carolina for Small Business: The Full Picture

South Carolina ranks #25 out of 50 for small business owners and entrepreneurs, with a mixed set of conditions for entrepreneurs. The state's fiscal health score of 54/100 is adequate, though fiscal conditions aren't a standout advantage.

Tax policy directly impacts the bottom line. South Carolina's overall tax burden is 8.15% of income, with a 6.2% income tax rate that applies to both personal and pass-through business income. The 7.49% combined sales tax rate is on the higher side and worth factoring into pricing strategy. The economic environment (score: 32/100) with 4.5% unemployment shows healthy labor availability.

Population growth of 1.46% is a tailwind — a growing customer base and expanding labor pool benefit most small businesses. Workforce quality may require investment in training — the education score of 50/100 suggests gaps in preparation. A typical home value of $306,323 is manageable for employees at typical small-business salary levels.

All 20 Cities Ranked for Small Business

#  CityGradeSmall Business scoreOverallHousehold financesEconomyGrowthPopulation
1Fort MillA+76.271.084749230,775
2BlufftonA66.163.681715533,157
3GreerB+64.361.558589241,536
4Mount PleasantA64.063.883783993,993
5Goose CreekB60.257.267586648,078
6CharlestonB+57.559.8586347154,338
7Hilton Head IslandB56.155.966613537,911
8AikenB55.056.042497832,521
9SummervilleC+54.452.757585151,654
10GreenvilleC+51.755.746524772,935
11North CharlestonC51.650.4414963119,913
12Rock HillC47.350.347433975,259
13ColumbiaC45.750.4203958139,643
14Carolina ForestD44.746.74934—26,263
15FlorenceD44.045.830404540,408
16ConwayD43.448.526275827,263
17AndersonD41.946.722394830,051
18Myrtle BeachF41.240.631414538,371
19SumterD40.543.834343643,053
20SpartanburgF37.740.119344238,910

City small business scores use each city's own data, with the category weights rescaled over the categories the city has; outdoor access has no city-level measure and is left out.

Compare: States with Similar Small Business Rankings

  • ColoradoSmall Business score 59.8#20
  • DelawareSmall Business score 59.5#21
  • VermontSmall Business score 59.3#22
  • WashingtonSmall Business score 58.8#23

Also See: South Carolina for Other Lifestyles

  • FamiliesFamilies score 55.8#40
  • RetireesRetirees score 54.0#40
  • Remote WorkersRemote Workers score 48.6#34
  • Young ProfessionalsYoung Professionals score 58.8#18
  • Outdoor EnthusiastsOutdoor Enthusiasts score 26.1#47

Frequently Asked Questions

Is South Carolina a good state for small business?

South Carolina ranks #25 out of 50 for small business with a persona-weighted score of 58.4/100. Its strongest relevant category is Affordability (78/100) and its weakest is Outdoor Access (9/100).

What is the best city for small business in South Carolina?

Fort Mill ranks #1 in South Carolina for small business with a score of 76.2/100, followed by Bluffton and Greer.

What factors are most important for small business in South Carolina?

Rankings weighted toward business-friendly tax climate, strong economy, population growth, workforce quality, and transportation infrastructure — what matters when starting or running a small business.